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CASPASES, INITIATOR
Descriptors Found:
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DeCS
Descriptor
English
:
Caspases, Initiator
Descriptor
Spanish
:
Caspasas Iniciadoras
Descriptor
Portuguese
:
Caspases Iniciadoras
Synonyms
English
:
Initiator Caspases
Tree Number:
D08.811.277.656.262.500.126.550
D08.811.277.656.300.200.126.550
D12.644.360.075.405.550
D12.776.476.075.405.550
Definition
English
:
A subtype of
caspases
that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor
proteins
such as
DEATH DOMAIN
RECEPTORS; DED SIGNALING ADAPTOR
PROTEINS
; and
CARD SIGNALING ADAPTOR PROTEINS
. Once activated, the
initiator caspases
can activate other
caspases
such as the
EFFECTOR CASPASES.
Entry Combination - descr/qualif
English
:
Caspases, Initiator
/
antagonists & inhibitors
use
Caspase Inhibitors
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52225
Unique Identifier:
D053471
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS